Mapping how kinases and their partner proteins change inside cells
Integrated mass spectrometry-based chemoproteomic and genomic technologies for studying dynamic kinase interactomes
['FUNDING_OTHER'] · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · NIH-11320819
This project is building lab tools to track how kinase proteins and their partners change in cells, which could help people with cancers and other diseases that hijack cell signaling.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11320819 on ClinicalTrials.gov |
What this research studies
Researchers are developing new chemical probes that enter cells and tag kinase proteins, then using crosslinking and proximity labeling to lock nearby protein and DNA interactions in place. Those tagged interactions will be read out with advanced liquid chromatography–mass spectrometry and sequencing to create maps of kinase-centered networks. The team will profile how these networks change over time and under different conditions relevant to disease and therapy resistance. The goal is to reveal dynamic wiring in cells that can point to new drug targets or explain why treatments stop working.
Who could benefit from this research
Good fit: People with cancers or other conditions driven by abnormal kinase signaling are the most likely future beneficiaries of therapies informed by this work.
Not a fit: Patients whose illnesses are unrelated to kinase signaling or who need immediate clinical treatment are unlikely to benefit directly from this laboratory-focused project.
Why it matters
Potential benefit: If successful, this work could reveal new drug targets and explain mechanisms of treatment resistance, enabling more precise and effective therapies.
How similar studies have performed: Related chemoproteomics and mass-spectrometry approaches have successfully profiled kinase interactions and drug binding, but combining cell-permeable probes with crosslinking and proximity labeling for global, dynamic mapping is a novel advance.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLKOWSKI, MARTIN — UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- Study coordinator: GOLKOWSKI, MARTIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.