Mapping how individual cells behave in living organisms over time
Single cell dynamics on a whole organism scale
This study is looking at how individual cells in mice change and interact as they get older, using special techniques to see how their behavior and gene activity differ between young and old mice, so we can better understand the effects of aging on our bodies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11064929 on NIH RePORTER |
What this research studies
This research investigates the dynamics of individual cells within mammalian organisms, focusing on how these cells behave and interact throughout the lifespan. By developing advanced techniques that allow for the simultaneous profiling of various cellular characteristics, including gene expression and cell behavior, the project aims to provide a comprehensive understanding of how aging affects cellular functions across different tissues. The research will utilize high-throughput single-cell RNA sequencing to monitor changes in cell states, such as proliferation and apoptosis, in both young and aged mice, offering insights into the biological processes of aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological processes of aging and how cellular dynamics may impact health as they age.
Not a fit: Patients with conditions unrelated to aging or cellular dynamics may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding aging and related diseases, potentially informing new therapeutic strategies.
How similar studies have performed: Other research has shown promise in using single-cell techniques to understand cellular behavior, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Cao, Junyue — Rockefeller University
- Study coordinator: Cao, Junyue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.