Mapping how human transcription factors interact with DNA
Official title: Expansion of the Human Transcription Factor Genome-wide Binding Map Resource
Funded at Hudson-Alpha Institute for Biotechnology · NIH-11066483 · Data updated 2026-11-12
This study is all about learning more about important proteins in our bodies that help control how our genes work, and it aims to create detailed maps showing where these proteins attach to DNA in different cell types, which could help us understand how they affect our health and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hudson-Alpha Institute for Biotechnology NIH-funded |
| Lab location | 1 site (Huntsville, United States) |
| Project start | April 4, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $673,380 |
| NIH project number | 5U24HG012922-02 |
| Project ID | NIH-11066483 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with genetic disorders or diseases where transcription factor activity is implicated.
✕Less likely to help
Patients with conditions unrelated to transcription factor activity or gene regulation may not receive direct benefits from this research.
What this research studies
This research focuses on expanding the understanding of human transcription factors (TFs), which are crucial for regulating gene expression and play significant roles in various biological processes and diseases. The project aims to create genome-wide binding maps for approximately 600 human TFs that currently lack this data, using advanced techniques like ChIP-seq and CETCh-seq. By generating these maps in relevant cell types, the research will provide valuable insights into how TFs function and interact with DNA, which could enhance our understanding of gene regulation in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of gene regulation, potentially informing new treatments for various diseases.
How similar studies have gone: Previous research has successfully mapped transcription factor interactions, indicating that this approach has a strong foundation and potential for impactful results.
Where this research is happening
-
Hudson-Alpha Institute for Biotechnology
Huntsville, United States Active
Researchers
- Principal investigator: Myers, Richard M — Hudson-Alpha Institute for Biotechnology
- Study coordinator: Myers, Richard M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.