Mapping how human B cells move and change in response to infections and diseases
Computational mapping of human B cell migration and differentiation pathways
This study is looking at how B cells, which are important for fighting infections and managing autoimmune diseases, move around in the body and change into different types when responding to illness, using advanced technology to get a clearer picture of their behavior in both healthy and sick people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10917325 on NIH RePORTER |
What this research studies
This research investigates the movement and transformation of human B cells, which are crucial for the immune response to infections and the development of autoimmune diseases. By utilizing advanced computational methods and single B cell sequencing technology, the study aims to track how B cells migrate between different tissues and differentiate into various functional types during immune responses. This approach seeks to overcome current limitations in observing these dynamic processes in humans, ultimately enhancing our understanding of B cell behavior in health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are affected by autoimmune diseases or have experienced infections requiring a robust immune response.
Not a fit: Patients who are under 21 years old or those without autoimmune conditions or significant immune response issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating infections and autoimmune diseases by enhancing our understanding of B cell dynamics.
How similar studies have performed: Previous research has successfully utilized phylogeographic methods in other contexts, suggesting potential for success in applying similar approaches to B cell dynamics.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Hoehn, Kenneth — Dartmouth College
- Study coordinator: Hoehn, Kenneth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.