Mapping how glioma spreads and changes over time using scans and tissue
Official title: Radiopathomic Modeling of Glioma Heterogeneity Throughout a Patient's Disease Trajectory
Funded at Medical College of Wisconsin · NIH-11267234 · Data updated 2026-11-12
Uses advanced MRI plus tissue samples and AI to create maps showing where glioma cells are hiding for adults with glioma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $663,952 |
| NIH project number | 5R01CA290631-02 |
| Project ID | NIH-11267234 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a diagnosis of glioma (newly diagnosed or recurrent) who can undergo MRI and provide or allow access to biopsy or tissue samples are the ideal candidates.
✕Less likely to help
People without glioma, children under 21, or those unwilling to share tissue samples or undergo the required imaging are unlikely to benefit from participation.
What this research studies
From a patient's perspective, researchers will combine MRI scans with biopsy and autopsy tissue from two hospitals to teach AI models how imaging relates to microscopic tumor cells. They will refine those models with clinical information and new deep-learning techniques and then test the combined tool in a prospective multi-site study across patients' treatment timelines. The work looks at tumor features at diagnosis and at recurrence to better show the true extent and heterogeneity of glioma. Participation may involve extra MRIs, sharing biopsy or tissue samples, and allowing researchers to use clinical records.
Why it matters
Potential benefit: If successful, this could give doctors clearer maps of where tumor cells extend beyond visible MRI, helping target treatments and judge response more accurately.
How similar studies have gone: Early single-center radio-pathomic studies have shown promise linking imaging to microscopic tumor features, but large multi-site prospective validation like this remains limited.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Laviolette, Peter S — Medical College of Wisconsin
- Study coordinator: Laviolette, Peter S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.