Mapping how genes work together in human diseases
Official title: MorPhiC: Constructing a Catalog of Cellular Programs to Identify and Annotate Human Disease Genes
Funded at Stanford University · NIH-10918248 · Data updated 2026-11-12
This study is looking at how different genes work together in specific cells to help us understand diseases better, which could lead to more personalized treatments for patients like you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $495,232 |
| NIH project number | 5U01HG013176-02 |
| Project ID | NIH-10918248 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases that have unclear underlying mechanisms.
✕Less likely to help
Patients with well-defined genetic disorders that are already fully understood may not benefit from this research.
What this research studies
This research aims to create a comprehensive catalog that details how different genes interact within specific cell types to influence human diseases. By utilizing advanced techniques such as CRISPR and single-cell analysis, the team will identify and annotate cellular programs that are crucial for understanding disease mechanisms. Patients can benefit from this research as it seeks to uncover the genetic pathways that contribute to various health conditions, potentially leading to more targeted treatments. The project will involve collaboration among experts in computational genomics and experimental design to ensure robust findings.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for a variety of human diseases by elucidating the genetic pathways involved.
How similar studies have gone: Other research has shown success in using similar genomic approaches to uncover disease mechanisms, indicating that this methodology is promising.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Engreitz, Jesse M — Stanford University
- Study coordinator: Engreitz, Jesse M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.