Mapping how genes work together in human diseases
MorPhiC: Constructing a Catalog of Cellular Programs to Identify and Annotate Human Disease Genes
This study is looking at how different genes work together in specific cells to help us understand diseases better, which could lead to more personalized treatments for patients like you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10918248 on NIH RePORTER |
What this research studies
This research aims to create a comprehensive catalog that details how different genes interact within specific cell types to influence human diseases. By utilizing advanced techniques such as CRISPR and single-cell analysis, the team will identify and annotate cellular programs that are crucial for understanding disease mechanisms. Patients can benefit from this research as it seeks to uncover the genetic pathways that contribute to various health conditions, potentially leading to more targeted treatments. The project will involve collaboration among experts in computational genomics and experimental design to ensure robust findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases that have unclear underlying mechanisms.
Not a fit: Patients with well-defined genetic disorders that are already fully understood may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for a variety of human diseases by elucidating the genetic pathways involved.
How similar studies have performed: Other research has shown success in using similar genomic approaches to uncover disease mechanisms, indicating that this methodology is promising.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Engreitz, Jesse M — Stanford University
- Study coordinator: Engreitz, Jesse M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.