Mapping how genes function in human cells using CRISPR technology
Spatial multiomic mapping of gene function with CRISPRoff
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10933518
This study is looking at how our genes affect our cells, using a special tool called CRISPRoff to safely turn off certain genes, and it aims to help us understand how these genes work during early development, which could lead to new treatments for health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10933518 on ClinicalTrials.gov |
What this research studies
This research aims to understand the relationship between genes and their effects on human cells by mapping gene functions. It utilizes a novel CRISPR technology called CRISPRoff, which allows for precise silencing of gene expression without causing DNA damage. By studying how specific genes influence cell behavior during early development, the research seeks to uncover the mechanisms behind gene regulation and its impact on health and disease. Patients may benefit from insights gained about gene functions that could lead to new treatments or therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or those interested in the genetic basis of diseases.
Not a fit: Patients with conditions unrelated to genetic expression or those not willing to participate in genetic research may not benefit.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding genetic diseases and developing targeted therapies.
How similar studies have performed: Other research using CRISPR technology has shown promising results in gene editing and regulation, indicating potential success for this approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GILBERT, LUKE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: GILBERT, LUKE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.