Mapping how genes are regulated in the human genome
A Comprehensive Genomic Community Resource of Transcriptional Regulation
This study is all about mapping important parts of our DNA that help control how our genes work, which could give researchers valuable clues about how changes in these areas might lead to diseases, ultimately helping patients understand more about their own health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11061753 on NIH RePORTER |
What this research studies
This research focuses on creating detailed atlases of regulatory elements in the human genome that control gene expression. By utilizing advanced techniques like ATAC sequencing, the project aims to identify and characterize non-coding regions that play crucial roles in transcriptional regulation. This comprehensive resource will help researchers understand how variations in these regulatory elements can lead to diseases. Patients may benefit from insights gained about the genetic factors influencing their conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with genetic disorders or those interested in the genetic basis of their health conditions.
Not a fit: Patients with conditions unrelated to genetic regulation or those not interested in genetic research may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic diseases and the development of targeted therapies.
How similar studies have performed: Previous large-scale projects like ENCODE have successfully mapped regulatory elements, indicating that this approach has a strong foundation in prior research.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Weng, Zhiping — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Weng, Zhiping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.