Mapping how DNA is accessed in living cells using light
Optogenomic mapping of chromatin accessibility in live cells
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY · NIH-10911271
This study is looking at how the way DNA is packed in our cells affects how easily it can be accessed, using a new tool that lets scientists see this process in real-time, which could help improve treatments for different health conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10911271 on ClinicalTrials.gov |
What this research studies
This research investigates how the structure of chromatin, which is the material that makes up chromosomes, affects the accessibility of DNA in live cells. By developing a new optogenetic tool, the researchers aim to measure chromatin accessibility in real-time without altering its natural state. This innovative approach will allow for a better understanding of how DNA regulatory elements function and how they are influenced by chromatin organization. Patients may benefit from insights gained into genetic regulation that could inform future therapies for various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or conditions related to chromatin accessibility and regulation.
Not a fit: Patients with conditions unrelated to chromatin structure or genetic regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding genetic regulation, potentially improving treatment strategies for genetic disorders.
How similar studies have performed: While chromatin accessibility studies have been conducted, this specific optogenetic approach is novel and has not been extensively tested in live cells.
Where this research is happening
Chicago, UNITED STATES
- NORTHWESTERN UNIVERSITY — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, XIAOZHONG ALEC — NORTHWESTERN UNIVERSITY
- Study coordinator: WANG, XIAOZHONG ALEC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.