Mapping how different brain cells connect and communicate
High-throughput mapping of synaptic connectivity between transcriptomically defined cell types
This study is exploring how different brain cells work together to affect how we think and behave, using new technology to create a detailed map of their connections, which could help us better understand brain function and related disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10413540 on NIH RePORTER |
What this research studies
This research focuses on understanding the intricate connections between various cell types in the brain, which is essential for grasping how our neural circuits influence perception, cognition, and behavior. By utilizing advanced optical and molecular technologies, the project aims to develop a new method for mapping synaptic connectivity at an unprecedented scale. This involves combining high-sensitivity fluorescence voltage imaging with single-neuron optogenetic stimulation to visualize how brain cells interact. The goal is to create a comprehensive map of these connections, which could enhance our understanding of brain function and disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions affecting cognition or memory, as well as healthy volunteers for comparative studies.
Not a fit: Patients with conditions unrelated to brain function or those who are not able to participate in neurological assessments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain disorders and improving treatments for cognitive impairments.
How similar studies have performed: Other research has shown promise in mapping brain connectivity using advanced imaging techniques, indicating that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Boston University (Charles River Campus) — Boston, United States (Active)
Researchers
- Principal investigator: Economo, Michael Nicholas — Boston University (Charles River Campus)
- Study coordinator: Economo, Michael Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.