Mapping how different aspects of aging interact in our cells
Using cellular co-biosis and age programmable mice to derive a global interaction map of aging hallmarks
This project explores how various signs of aging in our cells are connected, aiming to find new ways to slow down the aging process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11085276 on NIH RePORTER |
What this research studies
Our bodies naturally decline over time, a process linked to several "hallmarks of aging" that affect our tissues and overall health. Scientists are developing treatments to address these hallmarks and potentially slow aging. However, we don't fully understand how these different aging signs influence each other, which makes it difficult to create universally effective solutions. This work uses advanced methods to map these connections, helping us understand how cells lose their youthful information and how we might restore it.
Who could benefit from this research
Good fit: This foundational work is for anyone interested in the basic science of aging and its potential future impact on health.
Not a fit: Patients seeking immediate clinical treatments or direct participation in human trials would not directly benefit from this early-stage basic science.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for slowing down the aging process and preventing age-related diseases.
How similar studies have performed: Our lab has already developed systems to control aging in mammals and found that partial cellular reprogramming can reverse multiple signs of aging.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Sinclair, David a. — Harvard Medical School
- Study coordinator: Sinclair, David a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.