Mapping how chronic opioid use affects brain function in people with HIV
Integrative Single Cell isoform and chromatin accessibility Mapping of Chronic Opioid Exposure in Cognitive Brain Areas in HIV
['FUNDING_U01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10881897
This study is looking at how long-term use of opioids affects the brain in people living with HIV, especially in areas that are important for memory and decision-making, to find better ways to support brain health for those dealing with both conditions.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10881897 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of chronic opioid exposure on brain function in individuals living with HIV, focusing on specific brain regions known to be affected by both conditions. By using advanced techniques like single-cell RNA sequencing, the study aims to create detailed maps of cellular responses in the brain, particularly in the hippocampus and prefrontal cortex. The goal is to understand how opioid use disorder interacts with HIV persistence in the brain, which could lead to new strategies for improving brain health in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have a history of chronic opioid use.
Not a fit: Patients who do not have HIV or a history of opioid use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance brain health and reduce HIV persistence in patients with a history of opioid use.
How similar studies have performed: While there has been research on HIV and opioid use separately, this integrative approach using single-cell mapping is relatively novel and has not been extensively tested.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TILGNER, HAGEN ULRICH — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: TILGNER, HAGEN ULRICH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus