Mapping how cells regulate heart development
Fine-scale Spatiotemporal Mapping of Cellular Regulatory Networks Directing Heart Development
This study is looking at how certain genes work together to help the heart develop properly, especially in babies born with heart defects, and it aims to understand these processes better using mouse embryos.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10884381 on NIH RePORTER |
What this research studies
This research investigates the complex interactions of cellular regulators that guide the development of the heart, particularly focusing on congenital heart disease, which is the most common congenital anomaly in newborns. By employing a combination of experimental and computational methods, the project aims to define the gene regulatory networks that dictate the formation of various heart cell types during embryonic development. The research will analyze how these networks function over time and space in developing mouse embryos, providing insights into the cellular hierarchy that leads to a healthy heart.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include newborns diagnosed with congenital heart disease and their families.
Not a fit: Patients with acquired heart conditions or those over 21 years old without congenital heart disease may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and early identification of congenital heart diseases, potentially informing new treatment strategies.
How similar studies have performed: Previous research has shown success in understanding gene regulatory networks in other developmental contexts, suggesting that this approach could yield valuable insights into heart development as well.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Chi, Neil C — University of California, San Diego
- Study coordinator: Chi, Neil C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.