Mapping how cells interact in multiple sclerosis lesions
Generating spatial and functional maps of cell-to-cell interactions in MS lesions
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11042743
This study is looking at how different types of cells work together in the areas affected by multiple sclerosis, using special techniques to get a closer look at some less-studied cells, so we can better understand their roles and improve treatments for MS.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11042743 on ClinicalTrials.gov |
What this research studies
This research aims to create detailed maps of how different cells interact within lesions caused by multiple sclerosis (MS). By using advanced techniques like single nucleus RNA sequencing and flow sorting, the study will focus on capturing underrepresented cell types, such as astrocytes and microglia, to better understand their roles. The researchers will also employ computational tools to analyze these interactions and confirm findings through imaging techniques. Ultimately, this work seeks to enhance our understanding of cellular behavior in MS and its implications for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those experiencing acute or chronic lesions.
Not a fit: Patients with other neurological conditions unrelated to multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of multiple sclerosis, potentially informing more effective treatments.
How similar studies have performed: Previous studies using similar advanced sequencing and imaging techniques have shown promise in understanding cellular interactions in various diseases, suggesting potential for success in this novel approach.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PITT, DAVID — YALE UNIVERSITY
- Study coordinator: PITT, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.