Mapping how cells develop and differentiate in mice
Annotated lineage trees of murine development
['FUNDING_OTHER'] · DARTMOUTH COLLEGE · NIH-10472805
This study is looking at how different types of cells in mice develop and change over time, using cutting-edge tools to trace their journey from early stem cells to specialized intestinal cells, which could help improve medical treatments in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-10472805 on ClinicalTrials.gov |
What this research studies
This research investigates the processes that determine how cells develop and differentiate in mice, focusing on understanding the origins and relationships of various cell types. By utilizing advanced technologies such as CRISPR and molecular recording, the researchers aim to create detailed lineage maps that illustrate how intestinal cells evolve from embryonic stem cells. This work will involve tracking these cells through their development to provide insights into the molecular events that guide their fate. The findings could lead to a better understanding of cell differentiation, which is crucial for advancing medical treatments.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions related to cell differentiation and development, such as certain genetic disorders or cancers.
Not a fit: Patients with conditions unrelated to cell differentiation or those who are not affected by developmental processes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cell differentiation, potentially leading to breakthroughs in regenerative medicine and treatments for various diseases.
How similar studies have performed: Other research has shown success in using similar technologies for mapping cell differentiation, indicating that this approach has potential for significant findings.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCKENNA, AARON H — DARTMOUTH COLLEGE
- Study coordinator: MCKENNA, AARON H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.