Mapping how cells change across tissues using single-cell data
Landscapes for Cell State Transition Leveraging by Single-Cell Multi-Omics
['FUNDING_OTHER'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-11171630
This project builds new computer methods to trace how cells change in conditions like Alzheimer's disease and type 2 diabetes so researchers can find better treatment ideas.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11171630 on ClinicalTrials.gov |
What this research studies
Researchers will create mathematical tools and software that use large single-cell atlases to infer how cells move between states across different tissues and diseases. The approach combines gene activity and epigenetic information (multi-omics) to reconstruct cell fate changes without needing long-term tracking of individual cells. These tools will be applied to datasets related to Alzheimer's, diabetes, heart disease, and development to reveal disease mechanisms and regeneration processes. The goal is to make it easier for scientists to spot potential treatment targets and biomarkers from existing human tissue data.
Who could benefit from this research
Good fit: People with Alzheimer's disease, adult-onset (type 2) diabetes, heart failure, or those willing to donate tissue or data to single-cell research would be most relevant to this work.
Not a fit: Anyone without the listed conditions or those seeking immediate clinical treatments are unlikely to get direct benefit from these computational methods right away.
Why it matters
Potential benefit: If successful, this work could uncover new disease mechanisms and point to treatment targets or biomarkers that help people with Alzheimer's, diabetes, or heart disease.
How similar studies have performed: Large single-cell atlases and related computational methods have already advanced understanding of disease biology, but this specific reference-based dynamic inference approach is novel and exploratory.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, GUANGYU — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: WANG, GUANGYU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease