Mapping how cancer cells interact in their environment
SPATIALLY MAPPING OF POOLED IN VIVO CRISPR SCREENS IN THE TUMOR MICROENVIRONMENT
['FUNDING_OTHER'] · COLUMBIA UNIV NEW YORK MORNINGSIDE · NIH-10473150
This study is looking at how cancer cells interact with their surroundings to see how these interactions affect tumor growth and the immune system's response, with the hope of finding better ways to treat cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIV NEW YORK MORNINGSIDE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10473150 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between cancer cells and their surrounding environment to understand how these interactions influence tumor behavior and immune response. By using advanced techniques to analyze cells in their natural tissue context, the study aims to identify key signaling pathways that contribute to immune suppression in tumors. The approach involves innovative CRISPR screening methods that allow for the profiling of cellular interactions without removing cells from their native environment. This could lead to new insights into how to effectively target and treat cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with various types of cancer who are seeking innovative treatment options.
Not a fit: Patients with non-malignant conditions or those who are not currently undergoing cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in cancer therapies by identifying new targets for treatment that enhance immune response against tumors.
How similar studies have performed: Other research has shown success in using CRISPR technology to identify genetic regulators in cancer, suggesting that this approach has the potential for significant breakthroughs.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIV NEW YORK MORNINGSIDE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAUBLOMME, JELLERT — COLUMBIA UNIV NEW YORK MORNINGSIDE
- Study coordinator: GAUBLOMME, JELLERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer