Mapping how Barrett's esophagus changes across the esophagus over time
Multiscale modeling of spatiotemporal evolution in Barrett's esophagus
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11160630
Researchers will map genetic and epigenetic changes in Barrett's esophagus over time to help predict who may later develop esophageal cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11160630 on ClinicalTrials.gov |
What this research studies
If I take part, doctors would use tissue samples from my routine surveillance endoscopies to look at DNA and epigenetic marks across different spots and time points in my Barrett's segment. They combine detailed lab tests with computer models and evolutionary mapping to track how cell clones grow and spread in the tissue. The study uses samples from people who later developed cancer and from similar patients who did not, so patterns that signal future cancer may be identified. Results aim to turn those patterns into forecasts about cancer risk for individual patients.
Who could benefit from this research
Good fit: Ideal candidates are people with a diagnosis of Barrett's esophagus who undergo regular surveillance endoscopies and can provide tissue biopsy samples and clinical follow-up data.
Not a fit: People without Barrett's esophagus or those who already have advanced esophageal cancer are unlikely to benefit directly from this study.
Why it matters
Potential benefit: If successful, this work could lead to better ways to tell which patients with Barrett's esophagus are at high risk of progressing to cancer and who can stay on routine surveillance.
How similar studies have performed: Prior research has identified some genetic changes linked to progression, but this high-resolution, multi-omic and spatial evolutionary mapping approach is novel and goes beyond prior work.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CURTIUS, KATHLEEN M. — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: CURTIUS, KATHLEEN M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Barrett Syndrome