Mapping How Autism Genes Affect Brain Development
Scalable functional analysis of neuropsychiatric risk genes with spatially integrated in vivo Perturb-seq
This project aims to discover how specific genetic changes linked to autism and developmental delays affect brain cells and circuits.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11184361 on NIH RePORTER |
What this research studies
We want to understand how genetic changes associated with autism spectrum disorder (ASD) and neurodevelopmental delay (NDD) impact the brain. Our team will use advanced genetic screening methods to look at many genes at once, mapping their effects on specific brain regions and cell types. This will help us see how different genetic changes might lead to similar challenges in autism and pinpoint the exact brain areas and cell types involved. The goal is to build a detailed picture of how these genes work together to influence brain development.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding the genetic basis of autism spectrum disorder and neurodevelopmental delay.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal the fundamental causes of autism and developmental delays, paving the way for new treatments or interventions.
How similar studies have performed: This approach combines advanced genetic screening with spatial brain mapping, representing a novel and highly scalable method to understand complex gene functions.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Jin, Xin — Scripps Research Institute, the
- Study coordinator: Jin, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.