Mapping how antibodies recognize HIV
Complete mapping of immune selection from antibodies to HIV
This study is looking at how antibodies fight the HIV virus by examining its surface protein, and by understanding how different changes in the virus affect this battle, researchers hope to find better vaccines and treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10757423 on NIH RePORTER |
What this research studies
This research investigates how antibodies interact with the HIV virus, specifically focusing on the virus's surface protein, Env. By creating libraries of viruses with various mutations, the study aims to understand how these changes affect the ability of antibodies to recognize and neutralize the virus. The researchers will utilize advanced deep-sequencing techniques to analyze these interactions on a large scale, which could lead to the development of more effective vaccines and therapies against HIV. Patients may benefit from insights gained through this research that could improve treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV or those at high risk of HIV infection.
Not a fit: Patients who are not infected with HIV and have no risk factors for infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines and therapies for HIV, improving patient outcomes.
How similar studies have performed: Other research has shown promise in mapping antibody interactions with viruses, indicating that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Bloom, Jesse D — Fred Hutchinson Cancer Center
- Study coordinator: Bloom, Jesse D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.