Mapping how antibodies recognize HIV
High-throughput mapping of antigen specificity to B-cell-receptor sequence for characterizing antibody responses in HIV-vaccinated and infected individuals
This study is looking at how your immune system's antibodies react to HIV-1 infection and vaccines, with the goal of finding better ways to create vaccines and treatments for HIV by understanding these responses better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10686168 on NIH RePORTER |
What this research studies
This research focuses on understanding how the immune system's antibodies respond to HIV-1 infection and vaccination. By using advanced sequencing technologies, the study aims to link specific antibody sequences to their corresponding antigens in a high-throughput manner. This approach will allow researchers to analyze the complex antibody responses more effectively, which could lead to better vaccine designs and therapies for HIV. Patients may have their antibody responses characterized, providing insights into their immune response to HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been vaccinated against HIV or are currently infected with HIV.
Not a fit: Patients who are not affected by HIV or have not been vaccinated against it may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective HIV vaccines and therapies.
How similar studies have performed: Other research has shown promise in using advanced sequencing technologies to analyze antibody responses, indicating that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Georgiev, Ivelin — Vanderbilt University Medical Center
- Study coordinator: Georgiev, Ivelin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.