Mapping heart tissue changes related to age and sex.
Official title: Proteomics based mapping of cardiac extracellular matrix to define sex and age-dependent changes.
Funded at Methodist Hospital Research Institute · NIH-11083150 · Data updated 2026-11-12
This study looks at how the heart's support structure changes as we get older and how these changes might be different for men and women, helping us understand their effects on heart health and healing after injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $566,366 |
| NIH project number | 5R01AG080925-04 |
| Project ID | NIH-11083150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart conditions who are either young or elderly and may have varying sex hormone levels.
✕Less likely to help
Patients with non-cardiac conditions or those who do not fall into the age or sex categories being studied may not benefit from this research.
What this research studies
This research investigates how the extracellular matrix (ECM) in the heart changes with age and differs between males and females. By examining the proteins and structures within the ECM, the study aims to understand how these changes affect heart health and repair processes. The research involves using animal models to analyze the ECM's composition and its impact on cellular behavior, particularly in response to injury. This could lead to insights into how aging and sex differences influence heart disease outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart conditions by tailoring therapies based on age and sex differences.
How similar studies have gone: Previous research has shown that understanding ECM composition can lead to significant advancements in cardiac treatment, indicating that this approach has potential for success.
Where this research is happening
-
Methodist Hospital Research Institute
Houston, United States Active
Researchers
- Principal investigator: Cieslik, Katarzyna a. — Methodist Hospital Research Institute
- Study coordinator: Cieslik, Katarzyna a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.