Mapping genetic variations linked to psychiatric disorders across different ancestries
Official title: Whole chromosome fine-mapping integrating diverse ancestries for psychiatric disorders
Funded at Massachusetts General Hospital · NIH-10984631 · Data updated 2026-11-12
This study is working to better understand how our genes can affect mental health by looking closely at genetic information from different backgrounds, especially those that are often overlooked, so that researchers can find the specific genes linked to psychiatric disorders and help everyone more effectively.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $129,288 |
| NIH project number | 1K99MH135172-01A1 |
| Project ID | NIH-10984631 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse ancestral backgrounds, particularly those with psychiatric disorders.
✕Less likely to help
Patients with psychiatric disorders who are of exclusively European ancestry may not benefit directly from this research.
What this research studies
This research aims to improve the understanding of genetic factors contributing to psychiatric disorders by developing advanced statistical methods that account for diverse ancestries. It focuses on fine-mapping genetic variants from large datasets, particularly targeting non-European populations to reduce bias in findings. The project will create open-source tools and resources to analyze genetic data, enabling researchers to identify causal variants more accurately. By integrating data from various ancestries, the research seeks to enhance the resolution of genetic discoveries related to psychiatric conditions.
Why it matters
Potential benefit: If successful, this research could lead to more accurate identification of genetic risk factors for psychiatric disorders, ultimately improving diagnosis and treatment options for affected individuals.
How similar studies have gone: Previous research has shown success in genetic mapping approaches for diverse populations, indicating potential for impactful findings in this area.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Yuan, Kai — Massachusetts General Hospital
- Study coordinator: Yuan, Kai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.