Mapping genetic modifications and proteins in DNA using advanced sequencing techniques
Official title: Multiomic genomic mapping with long read sequencing
Funded at Epicypher, INC. · NIH-10917165 · Data updated 2026-11-12
This study is looking at how changes in DNA and proteins affect how our genes work, using a special technology that can read longer pieces of DNA, which could help doctors find better ways to diagnose and treat health conditions.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Epicypher, INC. NIH-funded |
| Lab location | 1 site (Research Triangle Park, UNITED STATES) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,270,748 |
| NIH project number | 5R44GM148145-03 |
| Project ID | NIH-10917165 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve complex genetic and epigenetic factors, such as cancer or genetic disorders.
✕Less likely to help
Patients with conditions that do not involve significant genetic or epigenetic components may not receive direct benefits from this research.
What this research studies
This research focuses on using advanced long-read sequencing technology to map genetic modifications and proteins associated with DNA. By analyzing longer segments of DNA, the study aims to provide a clearer understanding of how these modifications affect gene expression and cellular behavior. This approach allows researchers to investigate complex genomic regions that were previously difficult to study, potentially leading to new insights in biomedical research and drug development. Patients may benefit from improved diagnostic and therapeutic strategies based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnostics and targeted therapies for various diseases by enhancing our understanding of genetic and epigenetic factors.
How similar studies have gone: Other research has shown promising results using long-read sequencing technologies, indicating potential for significant advancements in genomic mapping.
Where this research is happening
-
Epicypher, INC.
Research Triangle Park, United States Active
Researchers
- Principal investigator: Burg, Jonathan Michael — Epicypher, INC.
- Study coordinator: Burg, Jonathan Michael
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This project is creating a new and more accurate way to map special DNA structures called R-loops, which are connected to aging and brain diseases like Alzheimer's.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.