Mapping genetic influences on brain function in autism and neurodevelopmental disorders
In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11011469
This study is looking at how certain genes might affect autism and developmental delays by exploring their impact on the brain, and it aims to create a new way to see how these genetic changes influence brain cells and their connections, helping us understand these conditions better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11011469 on ClinicalTrials.gov |
What this research studies
This research investigates how specific genetic variations contribute to autism spectrum disorder and neurodevelopmental delays by examining their effects on brain regions and neural circuits. Using advanced techniques, the team will develop a method called Perturb-map to conduct high-throughput genetic screenings in living brain tissues without the need for sectioning. This approach will allow researchers to visualize how genetic perturbations affect cell types, their locations, and connections within the brain, providing insights into the underlying mechanisms of these disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autism spectrum disorder or neurodevelopmental delays, as well as their families who may be interested in understanding the genetic aspects of these conditions.
Not a fit: Patients without a diagnosis of autism spectrum disorder or neurodevelopmental delays are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors involved in autism and neurodevelopmental disorders, potentially guiding new treatment strategies.
How similar studies have performed: Other research has shown success in using genetic screening techniques to understand neurodevelopmental disorders, making this approach promising yet innovative.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIN, XIN — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: JIN, XIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder