Mapping genetic influences on brain function in autism and neurodevelopmental disorders
Official title: In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues
Funded at Scripps Research Institute, the · NIH-11011469 · Data updated 2026-11-12
This study is looking at how certain genes might affect autism and developmental delays by exploring their impact on the brain, and it aims to create a new way to see how these genetic changes influence brain cells and their connections, helping us understand these conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | March 2, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $668,947 |
| NIH project number | 5R01HG012819-03 |
| Project ID | NIH-11011469 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autism spectrum disorder or neurodevelopmental delays, as well as their families who may be interested in understanding the genetic aspects of these conditions.
✕Less likely to help
Patients without a diagnosis of autism spectrum disorder or neurodevelopmental delays are unlikely to benefit from this research.
What this research studies
This research investigates how specific genetic variations contribute to autism spectrum disorder and neurodevelopmental delays by examining their effects on brain regions and neural circuits. Using advanced techniques, the team will develop a method called Perturb-map to conduct high-throughput genetic screenings in living brain tissues without the need for sectioning. This approach will allow researchers to visualize how genetic perturbations affect cell types, their locations, and connections within the brain, providing insights into the underlying mechanisms of these disorders.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors involved in autism and neurodevelopmental disorders, potentially guiding new treatment strategies.
How similar studies have gone: Other research has shown success in using genetic screening techniques to understand neurodevelopmental disorders, making this approach promising yet innovative.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Jin, Xin — Scripps Research Institute, the
- Study coordinator: Jin, Xin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.