Mapping genetic factors related to Alzheimer's Disease and brain imaging
Official title: Efficient IBD mapping for Alzheimer's Disease and related brain imaging phenotypes
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10803982 · Data updated 2026-11-12
This study is looking at how our genes might influence Alzheimer's Disease to help find better ways to diagnose and treat it, and it's designed for anyone interested in understanding more about this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 30, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $746,792 |
| NIH project number | 1R01AG081398-01A1 |
| Project ID | NIH-10803982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of Alzheimer's Disease or those exhibiting early signs of cognitive decline.
✕Less likely to help
Patients without a genetic predisposition to Alzheimer's Disease or those who are not experiencing cognitive issues may not benefit from this research.
What this research studies
This research investigates the genetic factors associated with Alzheimer's Disease (AD) by utilizing identical-by-descent (IBD) segments to enhance the understanding of genetic risk. The team will develop advanced statistical and computational methods to analyze large genetic datasets, specifically focusing on brain imaging phenotypes. By identifying novel genomic regions linked to AD, the research aims to provide insights that could lead to improved diagnostic and therapeutic strategies for patients. The findings will be shared publicly to encourage further research in this area.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for Alzheimer's Disease.
How similar studies have gone: Previous research has shown promise in using genetic mapping techniques to identify risk factors for Alzheimer's Disease, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Chen, Han — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Chen, Han
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.