Mapping genetic factors in the human brain related to Alzheimer's disease.
Official title: The BrainCellQTL consortium: QTL mapping in the human brain at the single cell level
Funded at Icahn School of Medicine at Mount Sinai · NIH-11071957 · Data updated 2026-11-12
This study is looking at how our genes might affect Alzheimer's disease by examining individual brain cells, which could help us find new ways to treat or prevent the disease in people who are at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 15, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $2,367,336 |
| NIH project number | 5U24AG087563-02 |
| Project ID | NIH-11071957 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those diagnosed with Alzheimer's or related dementias.
✕Less likely to help
Patients with no genetic predisposition to Alzheimer's disease or those with unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to Alzheimer's disease and related dementias by analyzing single cells from human brain tissue. By utilizing a large collection of single-cell libraries, the study aims to identify specific genetic variants that influence brain function and disease risk at a cellular level. This approach allows for a more precise understanding of how these genetic factors operate within different types of brain cells, potentially leading to new insights into the mechanisms of Alzheimer's disease. Patients may benefit from the findings as they could inform future treatments and preventive strategies.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that address the specific genetic causes of Alzheimer's disease.
How similar studies have gone: Previous research using similar single-cell analysis approaches has shown promise in understanding complex neurological disorders, indicating potential for success in this novel application.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Roussos, Panagiotis — Icahn School of Medicine at Mount Sinai
- Study coordinator: Roussos, Panagiotis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.