Mapping genetic factors in common variable immunodeficiency (CVID)
Promoter interactome-aided mapping of unexplored CVID genetic landscapes
This study is looking at the genes behind common variable immunodeficiency (CVID) to understand how certain DNA parts affect immune cells, which could help find better ways to diagnose and treat people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10640143 on NIH RePORTER |
What this research studies
This research investigates the genetic underpinnings of common variable immunodeficiency (CVID), a condition characterized by dysfunction in germinal centers, which are crucial for immune response. The study aims to identify non-coding regions of DNA that interact with gene promoters important for the function of B cells and T follicular helper cells. By analyzing these interactions, the research seeks to uncover how genetic variations contribute to the symptoms of CVID, potentially leading to new diagnostic and therapeutic strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with common variable immunodeficiency or those exhibiting symptoms of germinal center dysfunction.
Not a fit: Patients with autoimmune diseases unrelated to germinal center dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and targeted therapies for patients with CVID and related immune disorders.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in immune disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Romberg, Neil David — Children's Hosp of Philadelphia
- Study coordinator: Romberg, Neil David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.