Mapping genetic changes in Barrett's esophagus to understand cancer risk
Multiscale modeling of spatiotemporal evolution in Barrett's esophagus
This study is looking at the genes of people with Barrett's esophagus to find out which patients might be more likely to develop cancer, so doctors can provide better monitoring and treatment options for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10929960 on NIH RePORTER |
What this research studies
This research aims to create detailed genetic and epigenetic maps of Barrett's esophagus (BE), a condition that can lead to esophageal adenocarcinoma (EAC). By analyzing tissue samples collected over time from patients, the study will identify genetic markers that indicate the likelihood of BE progressing to cancer. The approach combines advanced genomic data with computational modeling to understand how cancerous cells evolve and spread within the tissue. This information could help in predicting which patients are at higher risk for developing cancer, allowing for more tailored surveillance and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with Barrett's esophagus who are undergoing regular surveillance for potential progression to cancer.
Not a fit: Patients without Barrett's esophagus or those who are not at risk for esophageal adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and prevention of esophageal cancer in patients with Barrett's esophagus.
How similar studies have performed: Previous research has shown promise in using genetic mapping to understand cancer progression, making this approach both innovative and grounded in prior successes.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Curtius, Kathleen M. — University of California, San Diego
- Study coordinator: Curtius, Kathleen M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.