Mapping genes linked to IBD in African American and Hispanic/Latinx people
IBD Gene Mapping by Clinical and Population Subset
This project looks for genetic differences that may explain Crohn’s disease and ulcerative colitis in African American and Hispanic/Latinx people.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11137643 on NIH RePORTER |
What this research studies
If I join, researchers will collect my clinical information and biological samples (like blood) and link those to genetic tests to find DNA differences tied to IBD. They are focusing on carefully describing symptoms and disease course in African-American patients and will also recruit Hispanic/Latinx patients for parallel work. The team will use large-scale genetic scans (GWAS), fine-mapping, sex-stratified analyses, ATAC-seq related methods, and combine data across centers to pinpoint risk regions and shared immune-disease genes. Participation may involve clinic visits, questionnaires, and providing samples so my data can be included in consortium analyses.
Who could benefit from this research
Good fit: Ideal candidates are African-American individuals with Crohn’s disease or ulcerative colitis, and Hispanic/Latinx patients with IBD, who can provide clinical information and biological samples for genetic study.
Not a fit: People without IBD or those from ancestry groups not included in this project are unlikely to see direct benefits from this ancestry-focused genetic research.
Why it matters
Potential benefit: If successful, this work could reveal genetic risk factors that improve diagnosis, risk prediction, and lead to better-targeted treatments for African American and Hispanic/Latinx people with IBD.
How similar studies have performed: Previous large GWAS have identified over 200 IBD-associated regions, but relatively few studies focused on African-American or Hispanic/Latinx groups, so this targeted approach builds on proven methods while addressing underrepresented populations.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Brant, Steven R — Rutgers Biomedical and Health Sciences
- Study coordinator: Brant, Steven R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.