Mapping gene activity in Giardia during its transformation into cysts
Single-cell transcriptional atlas of Giardia encystation
This study is looking at how the Giardia parasite changes into a dormant form to survive and spread, and by understanding this process better, researchers hope to find new ways to treat and prevent infections for people who are affected by it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11072880 on NIH RePORTER |
What this research studies
This research investigates how the parasite Giardia transforms into dormant cysts, a process that is crucial for its survival and transmission. By using advanced single-cell RNA sequencing techniques, the researchers aim to create a detailed map of gene expression during this transformation. Understanding the signals that trigger this process could lead to new strategies for treating Giardia infections and preventing their spread. The study focuses on identifying the molecular pathways involved in encystation, which could provide insights into controlling this common intestinal parasite.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Giardia infections or are at risk of infection.
Not a fit: Patients who do not have Giardia infections or are not at risk of exposure to this parasite may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively clear Giardia infections and reduce transmission rates.
How similar studies have performed: Previous research has shown success in using single-cell RNA sequencing to understand other parasitic infections, indicating that this approach may yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Paredez, Alexander Richard — University of Washington
- Study coordinator: Paredez, Alexander Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.