Mapping gene activity in Giardia during its transformation into cysts
Official title: Single-cell transcriptional atlas of Giardia encystation
Funded at University of Washington · NIH-11072880 · Data updated 2026-11-12
This study is looking at how the Giardia parasite changes into a dormant form to survive and spread, and by understanding this process better, researchers hope to find new ways to treat and prevent infections for people who are affected by it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | February 24, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $218,767 |
| NIH project number | 1R21AI188716-01 |
| Project ID | NIH-11072880 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with Giardia infections or are at risk of infection.
✕Less likely to help
Patients who do not have Giardia infections or are not at risk of exposure to this parasite may not benefit from this research.
What this research studies
This research investigates how the parasite Giardia transforms into dormant cysts, a process that is crucial for its survival and transmission. By using advanced single-cell RNA sequencing techniques, the researchers aim to create a detailed map of gene expression during this transformation. Understanding the signals that trigger this process could lead to new strategies for treating Giardia infections and preventing their spread. The study focuses on identifying the molecular pathways involved in encystation, which could provide insights into controlling this common intestinal parasite.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively clear Giardia infections and reduce transmission rates.
How similar studies have gone: Previous research has shown success in using single-cell RNA sequencing to understand other parasitic infections, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Paredez, Alexander Richard — University of Washington
- Study coordinator: Paredez, Alexander Richard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.