Mapping fat cell types and aging cells in older adults
Single nuclei RNA-sequencing to map adipose cellular populations and senescent cells in older subjects
This study is looking at how getting older changes the different types of cells in fat tissue, especially in older adults, to better understand how these changes might be linked to age-related health issues like Alzheimer's and diabetes, and we’re inviting patients to help by providing fat tissue samples for our research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11076799 on NIH RePORTER |
What this research studies
This research investigates how aging affects the different types of cells found in fat tissue, particularly in older adults. By using a cutting-edge technique called single nuclei RNA sequencing, the study aims to identify and categorize various cellular populations within adipose tissue, including those that may contribute to age-related diseases like Alzheimer's and diabetes. The research focuses on understanding how these cellular changes relate to inflammation and metabolic dysfunction, which are common in aging. Patients may be involved in providing adipose tissue samples to help researchers gain insights into the cellular dynamics of aging.
Who could benefit from this research
Good fit: Ideal candidates for participation are older adults, particularly those experiencing age-related conditions such as obesity, diabetes, or Alzheimer's disease.
Not a fit: Patients who are younger than 21 years old or do not have age-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases linked to fat tissue dysfunction.
How similar studies have performed: Previous research using single-cell RNA sequencing has shown promise in understanding cellular populations in various tissues, suggesting that this approach could yield valuable insights in this context as well.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Musi, Nicolas — Cedars-Sinai Medical Center
- Study coordinator: Musi, Nicolas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.