Mapping epigenetic changes in ovarian tumors at the single-cell level
Single cell chromatin profiling to study epigenetic alterations of ovarian tumors
This study is looking at how changes in the genes of ovarian tumors affect their behavior and treatment responses, especially focusing on a specific enzyme called EZH2, to find new ways to help personalize treatments for patients with ovarian cancer.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10692705 on NIH RePORTER |
What this research studies
This research investigates how epigenetic alterations affect ovarian tumors by using advanced single-cell genome profiling technology. The approach focuses on characterizing different cell populations within ovarian tumors, including cancer stem cells, to understand how these changes influence tumor behavior and treatment responses. By examining the role of the EZH2 enzyme, which is often overexpressed in ovarian cancer, the research aims to uncover how inhibiting this enzyme can impact tumor aggressiveness and promote differentiation. This could lead to the development of new therapeutic strategies tailored to the unique characteristics of individual tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with ovarian cancer, particularly those with aggressive or advanced disease.
Not a fit: Patients with non-cancerous conditions or those with early-stage ovarian cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for ovarian cancer by targeting specific epigenetic changes.
How similar studies have performed: Other research has shown promising results using similar single-cell profiling technologies to understand cancer biology, indicating potential for success in this approach.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Gopalan, Sneha — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Gopalan, Sneha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.