Mapping eczema biology across ethnic groups and levels of severity
Developing a Molecular Map of Atopic Dermatitis Across Ethnicity and Severity Subtypes.
This project looks at skin and blood differences in adults with moderate-to-severe atopic dermatitis across different ethnic groups to help match treatments to each person's type of eczema.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11332655 on NIH RePORTER |
What this research studies
You would be asked to provide skin samples and blood so researchers can compare molecular signals in people with different eczema severities and ethnic backgrounds. The team will profile both lesional and non-lesional skin plus circulating immune signals to see when inflammation becomes systemic. By including adults from African and Asian populations and comparing them to U.S. African American and Asian American patients, they aim to find shared and distinct molecular patterns. Those patterns could point to when topical care is enough and when systemic treatments may be needed.
Who could benefit from this research
Good fit: Adults with moderate-to-severe atopic dermatitis, particularly people of African or Asian ancestry or African American/Asian American backgrounds, are the ideal candidates.
Not a fit: People without atopic dermatitis or those with only very mild, occasional eczema are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, the work could help doctors choose treatments better matched to your specific eczema type.
How similar studies have performed: Previous studies have found distinct molecular patterns in some eczema subtypes, but a large multi-ethnic mapping effort of this scope is relatively new.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Guttman, Emma — Icahn School of Medicine at Mount Sinai
- Study coordinator: Guttman, Emma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.