Mapping dopamine activity in the brain related to movement disorders
Mapping neurochemical activity of the basal ganglia in pathological behaviors
This study is looking at how dopamine, a brain chemical, influences movement and mood in animals to help us find better treatments for people with Parkinson's disease and similar movement disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10685309 on NIH RePORTER |
What this research studies
This research investigates how dopamine activity in the basal ganglia affects behaviors associated with movement disorders like Parkinson's disease. By using advanced techniques to measure dopamine signals in nonhuman primates, the study aims to understand the specific roles of dopamine in motor and mood behaviors. The researchers will employ fast scan cyclic voltammetry to capture real-time dopamine activity, which could lead to better-targeted therapies for patients suffering from these debilitating conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or other movement disorders characterized by dopamine dysregulation.
Not a fit: Patients with movement disorders not primarily linked to dopamine dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for movement disorders, enhancing the quality of life for patients.
How similar studies have performed: Previous research has shown promise in mapping neurochemical activity in related areas, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Schwerdt, Helen N — University of Pittsburgh at Pittsburgh
- Study coordinator: Schwerdt, Helen N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.