Mapping DNA changes in the brain related to mental health during development.
1/3 High-resolution mapping of cell type-specific DNA (hydroxy)methylation in the human brain during postnatal development and in psychiatric disease.
This study is looking at how changes in DNA in the brain might be connected to mental health issues like schizophrenia and bipolar disorder, especially during important growth periods, to help us understand what might cause these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10816573 on NIH RePORTER |
What this research studies
This research investigates how specific DNA modifications in the brain are linked to mental health disorders, particularly during critical developmental stages. By analyzing DNA methylation patterns in brain cells, the study aims to identify genetic factors that may contribute to conditions like schizophrenia and bipolar disorder. The approach involves advanced techniques that allow for high-resolution mapping of these changes, providing insights into how they may affect brain function and behavior. This research could lead to a better understanding of the biological underpinnings of psychiatric diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include adolescents and adults with a history of psychiatric disorders such as schizophrenia or bipolar disorder.
Not a fit: Patients without any psychiatric disorders or those who are not within the specified age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and treatments for mental health disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of DNA methylation in psychiatric disorders, indicating that this approach has potential for success.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Liu, Chunyu — Upstate Medical University
- Study coordinator: Liu, Chunyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.