Mapping DNA changes in the brain related to development and mental health
2/3 High-resolution mapping of cell type-specific DNA (hydroxy)methylation in the human brain during postnatal development and in psychiatric disease
This study is looking at how changes in DNA in the brain during development might be connected to mental health issues, with the hope that understanding these changes can help improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10831485 on NIH RePORTER |
What this research studies
This research investigates how specific DNA modifications in the brain change during development and are linked to psychiatric disorders. By focusing on cell type-specific DNA methylation and hydroxymethylation, the study aims to identify critical regulatory elements that influence gene expression in the brain. Using advanced sequencing techniques, researchers will analyze these modifications with high precision, which could lead to a better understanding of the biological underpinnings of mental health conditions. Patients may benefit from insights gained into how these DNA changes relate to their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with psychiatric disorders such as schizophrenia or bipolar disorder, as well as healthy participants for comparative analysis.
Not a fit: Patients without psychiatric disorders or those not interested in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for psychiatric disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetic changes in psychiatric disorders, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Dracheva, Stella — Icahn School of Medicine at Mount Sinai
- Study coordinator: Dracheva, Stella
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.