Mapping dangerous seizures in the brain
Secondarily generalized tonic clonic seizure; a functional anatomy
This study is looking at how mild seizures can turn into more serious ones that can be dangerous, and it's for people with epilepsy who want to understand more about their condition and potential new treatments.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10913532 on NIH RePORTER |
What this research studies
This research investigates how focal motor seizures can develop into more severe bilateral tonic-clonic seizures, which pose significant risks to patients, including sudden unexpected death in epilepsy (SUDEP). The study aims to understand the brain circuits involved in this process by using advanced 3D imaging and tracing techniques in specially designed mice. By examining the pathways in the brain that contribute to these seizures, the research seeks to uncover new insights into their mechanisms and potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with epilepsy who experience focal motor seizures that may progress to tonic-clonic seizures.
Not a fit: Patients who do not have epilepsy or those whose seizures are well-controlled and do not progress to tonic-clonic seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of severe seizures, potentially reducing the risk of SUDEP and related injuries.
How similar studies have performed: Other research has shown success in mapping brain circuits related to seizures, indicating that this approach has potential for meaningful advancements in understanding seizure dynamics.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Kapur, Jaideep — University of Virginia
- Study coordinator: Kapur, Jaideep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.