Mapping changes in immune cell gene regulation
Quantitative mapping of dynamic epigenetic states in rare and stimulated immune cells
['FUNDING_SBIR_2'] · EPICYPHER, INC. · NIH-10895434
This study is looking at how changes to certain proteins that help organize our DNA can influence how immune cells work, especially in rare types of these cells, to find new ways to understand and treat immune and inflammatory diseases.
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EPICYPHER, INC. (nih funded) |
| Locations | 1 site (Research Triangle Park, UNITED STATES) |
| Trial ID | NIH-10895434 on ClinicalTrials.gov |
What this research studies
This research investigates how specific chemical modifications to histones, which are proteins that help package DNA, affect gene expression in immune cells. By focusing on rare immune cell types and their responses to stimulation, the project aims to uncover new regulatory mechanisms linked to immune and inflammatory diseases. The researchers are developing a novel, ultra-sensitive genomics platform called EpiPrime-seqTM to better analyze these modifications in primary immune cells, overcoming limitations of existing methods. This approach could lead to a deeper understanding of how immune responses are regulated at the molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with immune or inflammatory diseases who may benefit from a better understanding of their condition at a molecular level.
Not a fit: Patients with stable, non-inflammatory conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for immune and inflammatory diseases.
How similar studies have performed: Other research has shown success with similar approaches in studying chromatin dynamics, but this specific method is novel and untested.
Where this research is happening
Research Triangle Park, UNITED STATES
- EPICYPHER, INC. — Research Triangle Park, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KEOGH, MICHAEL-CHRISTOPHER — EPICYPHER, INC.
- Study coordinator: KEOGH, MICHAEL-CHRISTOPHER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.