Mapping cellular changes in the hippocampus related to aging and Alzheimer's disease
Official title: Spatially resolved multi-omics profiling of human hippocampus in Aging and Alzheimer's Disease
Funded at University of Pennsylvania · NIH-11086630 · Data updated 2026-11-12
This study is looking at how aging and Alzheimer's disease change the brain's memory area, the hippocampus, and it needs your help by providing tissue samples or joining in related activities to better understand these changes and find new ways to help with memory problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $603,404 |
| NIH project number | 5R01AG085344-02 |
| Project ID | NIH-11086630 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals diagnosed with Alzheimer's disease or those experiencing memory impairment related to aging.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research investigates the complex cellular structures of the human hippocampus, particularly how they are affected by aging and Alzheimer's disease. By developing innovative technology to analyze the epigenome, transcriptome, and proteins in tissue samples, the study aims to create detailed maps of cellular states and their environments. This approach will help identify specific cell types and their roles in memory impairment associated with Alzheimer's, potentially leading to new therapeutic strategies. Patients may contribute by providing tissue samples or participating in related assessments.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers and targeted therapies for Alzheimer's disease, improving memory function and overall quality of life for patients.
How similar studies have gone: Previous research has shown promise in using multi-omics approaches to understand complex diseases, suggesting that this innovative method could yield valuable insights into Alzheimer's disease.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Deng, Yanxiang — University of Pennsylvania
- Study coordinator: Deng, Yanxiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.