Mapping cellular aging in lung and heart tissues
Bio-Analysis-Core
This study is looking at how getting older affects the lungs and heart by mapping out the changes in cells that stop dividing, which can lead to health issues, and it's designed to help doctors understand how these changes might influence treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10923859 on NIH RePORTER |
What this research studies
This research focuses on understanding how aging affects the lung and heart tissues by creating a detailed map of cellular senescence, which is the process where cells stop dividing and can contribute to aging and disease. Using advanced technologies, researchers will analyze healthy and aged tissues to identify specific markers that indicate cellular aging. The study employs high-resolution imaging, multi-omics approaches, and sophisticated data analysis to uncover the complexities of senescent cells and their impact on health. By identifying these markers, the research aims to predict how patients might respond to potential therapies that target senescent cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults or individuals with age-related conditions affecting lung and heart health.
Not a fit: Patients with acute conditions unrelated to aging or cellular senescence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve health outcomes for aging patients by targeting harmful senescent cells.
How similar studies have performed: Previous research has shown promise in understanding cellular senescence and its implications for aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Koenigshoff, Melanie — University of Pittsburgh at Pittsburgh
- Study coordinator: Koenigshoff, Melanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.