Mapping cellular aging in different tissues of mice
Data Analysis Core
['FUNDING_OTHER'] · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · NIH-10889161
This study is looking at how aging affects different parts of the body in mice, like the brain and liver, by examining their cells to see what changes happen as they get older, which could help us understand aging better and improve health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10889161 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how cellular aging, specifically cellular senescence, affects various tissues in mice, including the brain, bone marrow, colon, breast, and liver. By analyzing genetic and epigenetic data from both young and old mice, the researchers aim to create a detailed map of cellular profiles that highlight differences in aging across these tissues. The study employs advanced computational techniques to process data from single-cell sequencing and imaging, allowing for the identification of specific populations of aging cells and their characteristics. This comprehensive approach will help uncover the mechanisms behind cellular aging and its implications for health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those with age-related conditions.
Not a fit: Patients who are not experiencing age-related conditions or are not interested in the biological aspects of aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into aging and potential therapeutic targets for age-related diseases.
How similar studies have performed: Other research has shown success in mapping cellular aging and its effects on health, indicating that this approach is promising and builds on established findings.
Where this research is happening
LA JOLLA, UNITED STATES
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REN, BING — SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Study coordinator: REN, BING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.