Mapping cancer vulnerabilities to improve treatment options
Advanced development of the Cancer Dependency Map portal (DepMap.org)
This study is looking at the genetic weaknesses of different types of cancer using advanced technology, so that doctors can find better, more personalized treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10904866 on NIH RePORTER |
What this research studies
This research focuses on creating a comprehensive database that identifies the genetic vulnerabilities of various cancer types. By utilizing advanced CRISPR technology, the project analyzes over 1,000 cancer cell lines to determine which genetic alterations are essential for tumor survival. This information will help researchers and clinicians understand how to target these vulnerabilities with specific therapies, ultimately leading to more personalized treatment options for patients. The data generated will be made available through an online portal, allowing for widespread access and collaboration among the scientific community.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who have undergone genetic sequencing of their tumors.
Not a fit: Patients with cancers that do not have well-defined genetic vulnerabilities or those who are not undergoing genetic testing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments by identifying specific genetic targets for therapy.
How similar studies have performed: Other research initiatives utilizing CRISPR technology to map cancer dependencies have shown promising results, indicating that this approach is both innovative and supported by prior successes.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Montgomery, Philip — Broad Institute, INC.
- Study coordinator: Montgomery, Philip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.