Mapping brain tissues using advanced sequencing techniques
Highly scalable and sensitive spatial transcriptomic and epigenomic sequencing of brain tissues from human and non-human primate
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-10370074
This study is testing a new technology that helps scientists take detailed pictures of brain tissues from humans and monkeys to better understand how different types of brain cells work together, making it easier for researchers to explore brain function and structure.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10370074 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a novel technology called DBiT-seq, which allows for high-resolution mapping of brain tissues from both humans and non-human primates. By utilizing spatial transcriptomics and epigenomics, the project aims to profile various cell types and their relationships within the brain, providing insights into the complex organization of neural and non-neural cells. The methodology is designed to be user-friendly, requiring minimal experience in advanced imaging or microfluidics, making it accessible for broader applications in neuroscience. The research will specifically target six distinct brain regions to enhance our understanding of brain function and structure.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurological conditions or those interested in the biological underpinnings of brain aging.
Not a fit: Patients with conditions unrelated to brain function or those who do not reside in the geographic area of the research may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding brain disorders and aging, potentially informing new therapeutic strategies.
How similar studies have performed: Other research has shown success with similar spatial omics approaches, indicating a promising avenue for breakthroughs in understanding brain biology.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FAN, RONG — YALE UNIVERSITY
- Study coordinator: FAN, RONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.