Mapping brain language areas using advanced EEG techniques
Diagnostic validity and safety of high-gamma language mapping with intracranial EEG
This study is testing a new, safer way to find the parts of the brain that control language, which could help people with epilepsy get better care before their surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10836478 on NIH RePORTER |
What this research studies
This research investigates a new method for identifying language areas in the brain using high-gamma language mapping with intracranial EEG. The approach aims to improve patient safety and diagnostic accuracy compared to traditional electrical cortical stimulation mapping, which can cause discomfort and complications. By analyzing brain activity related to language tasks, the study seeks to provide a more reliable way to localize critical language regions before epilepsy surgery. The research involves collaboration among three major academic epilepsy surgery centers to validate this technique.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults and children with drug-resistant epilepsy who are considering surgical options.
Not a fit: Patients who do not have epilepsy or those whose condition is not drug-resistant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective epilepsy surgeries, reducing the risk of post-operative language impairments.
How similar studies have performed: Previous research has shown promise in using high-gamma mapping techniques, but this study aims to provide more definitive validation in a larger, multi-center setting.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Crone, Nathan E — Johns Hopkins University
- Study coordinator: Crone, Nathan E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.