Mapping brain function to discover Alzheimer's biomarkers
Official title: Individual functional brain mapping for biomarker discovery in Alzheimer's
Funded at Trustees of Indiana University · NIH-11164602 · Data updated 2026-11-12
This study is looking for new ways to spot Alzheimer's disease early by using brain scans and blood tests, so that people at risk can get the help they need and join clinical trials more easily.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | August 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $693,500 |
| NIH project number | 5R01AG083919-02 |
| Project ID | NIH-11164602 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who are at risk of developing Alzheimer's disease or are experiencing early cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's disease or those who do not have any cognitive impairment may not benefit from this research.
What this research studies
This research aims to develop new biomarkers for Alzheimer's disease (AD) by using functional magnetic resonance imaging (fMRI) to study brain connectivity and organization. The goal is to create non-invasive screening methods that can identify individuals at risk of cognitive decline and track those eligible for new treatments. By combining fMRI with blood tests and existing imaging techniques, the researchers hope to establish a comprehensive approach to diagnosing and monitoring AD. This could make it easier for patients to participate in clinical trials and receive timely interventions.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate identification of Alzheimer's disease, improving treatment options for patients.
How similar studies have gone: Previous research has shown promise in using fMRI for brain mapping in Alzheimer's, but this specific approach to developing biomarkers is still novel.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Mejia, Amanda — Trustees of Indiana University
- Study coordinator: Mejia, Amanda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.