Mapping Brain Differences in Mental Health Conditions
Official title: Mapping heterogeneity of brain microstructural abnormalities in psychiatric disorders with normative modelling
Funded at Ohio State University · NIH-11142563 · Data updated 2026-11-12
This project looks at individual brain differences to better understand mental health conditions and how treatments might work best for each person.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $730,500 |
| NIH project number | 5R01MH130362-03 |
| Project ID | NIH-11142563 on NIH RePORTER |
Who could benefit from this research
✓Could help
This project primarily uses existing brain scan data, so direct patient participation in data collection is not currently part of the grant, but future clinical applications would benefit individuals with psychiatric disorders.
✕Less likely to help
Patients not experiencing psychiatric disorders or those whose conditions are not related to brain microstructure may not directly benefit from this specific research.
What this research studies
The goal is to create a detailed map of brain structure across different ages, using information from over 50,000 existing brain scans. This map will help us understand what a 'normal' brain looks like at various life stages. By comparing individual brain scans to this normal range, we hope to find unique patterns in people with mental health conditions. This approach could lead to more personalized treatments, moving away from a one-size-fits-all approach in psychiatry.
Why it matters
Potential benefit: If successful, this work could help doctors better understand individual brain differences in psychiatric disorders, leading to more personalized and effective treatment plans.
How similar studies have gone: Normative modeling is a developing field, and while some studies have shown promise in using individual brain data, this comprehensive approach across the lifespan with such a large dataset is a significant advancement.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Kraguljac, Nina Vanessa — Ohio State University
- Study coordinator: Kraguljac, Nina Vanessa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.