Mapping brain connectivity using advanced imaging techniques
Label-free optical imaging for human mesoscale connectivity with a focus on deep brain stimulation targets
This study is exploring how brain cells connect with each other to help improve treatments for conditions like depression or epilepsy, using a new imaging method to create a detailed map of these connections, which could lead to better therapies for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11010872 on NIH RePORTER |
What this research studies
This research focuses on understanding how different sets of neurons in the brain connect with each other, which is crucial for treating neurological and psychiatric disorders. By developing a novel imaging technique called depth-resolved polarized light imaging, the project aims to create a detailed map of brain wiring at a microscopic level. This technique will visualize axons and fiber tracts, providing insights into how deep brain stimulation therapies can normalize connectivity in affected areas. Patients may benefit from improved treatment strategies based on this enhanced understanding of brain connectivity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from neurological or psychiatric disorders that may benefit from deep brain stimulation.
Not a fit: Patients with conditions that do not involve abnormal brain connectivity or those who are not candidates for deep brain stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective deep brain stimulation therapies for patients with neurological and psychiatric disorders.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques to map brain connectivity, suggesting that this approach could yield significant insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Akkin, Taner — University of Minnesota
- Study coordinator: Akkin, Taner
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.