Mapping brain connections in primates using advanced technology
BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding
['FUNDING_U01'] · BROAD INSTITUTE, INC. · NIH-10867065
This study is exploring how brain connections work in marmosets to help us better understand how the brain processes information, which could lead to new insights about brain function and disorders that we can't get from studying mice.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROAD INSTITUTE, INC. (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10867065 on ClinicalTrials.gov |
What this research studies
This research investigates the intricate synaptic connections in the primate brain, which are crucial for understanding neural computation. By utilizing innovative techniques, the study aims to deliver barcoded RNAs to specific brain regions and map the projections of midbrain dopaminergic neurons in marmosets. The approach combines systemic AAV delivery with advanced transcriptomics to achieve unprecedented resolution in quantifying synaptic structures. This could provide insights into brain function and disorders that are not possible with current rodent models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that affect brain connectivity or function.
Not a fit: Patients with conditions unrelated to brain connectivity or those who do not have access to the research facilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function and lead to new treatments for neurological disorders.
How similar studies have performed: While similar approaches have been successful in rodent models, this research represents a novel application in primates, which has not been extensively tested.
Where this research is happening
CAMBRIDGE, UNITED STATES
- BROAD INSTITUTE, INC. — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACOSKO, EVAN Z — BROAD INSTITUTE, INC.
- Study coordinator: MACOSKO, EVAN Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.