Mapping brain connections and gene activity at the single-cell level
High-throughput sequencing of synaptic partnerships and gene expression at single-cell resolution in vivo
This study is exploring how brain cells talk to each other and connect, using a new technique that looks at many individual cells at once, so we can learn more about how these connections work in a friendly and detailed way.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10506110 on NIH RePORTER |
What this research studies
This research investigates how neurons in the brain connect and communicate with each other by using a novel method called SBARRO, which allows for the simultaneous measurement of synaptic connections and gene expression in individual cells. By employing high-throughput single-cell RNA sequencing, the study aims to analyze large numbers of neurons to better understand the molecular mechanisms that govern these connections. This approach overcomes limitations of traditional methods that only sample a few cells, providing a more comprehensive view of brain connectivity in living organisms.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological conditions that affect synaptic function or connectivity.
Not a fit: Patients with conditions unrelated to synaptic connectivity or those who do not have access to the research facilities may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain function and the development of targeted therapies for neurological disorders.
How similar studies have performed: Previous research using similar high-throughput sequencing techniques has shown promise in mapping neural connections, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Saunders, Arpiar B — Oregon Health & Science University
- Study coordinator: Saunders, Arpiar B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.